Molecular Geometry

For the discussion, pick a topic of your choice that is related to this week’s reading material-Molecular Geometry. Molecular geometries of molecules often play an important role in determining the properties and/or function of that molecule, especially in biological molecules. Take for example, protein folding, which is part of the post-translational process proteins regularly undergo. In most cases, proteins are modified and properly folded, that is, they end up with the structure and function that genetics (DNA) indicated they would. In some cases, however, a mutation is introduced during abnormal transcription-translation (DNA-RNA- protein), two or more amino acids change their position within the protein molecule, new bonds (hydrogen, S-S, etc.) are formed or old bonds are disrupted causing change in protein conformation. One of such scenarios is familial Alzheimer’s disease resulting from mutated and misfolded protein, called presenilin (PS1). Mutations cause PS1 to adopt “closed” or compact conformation that is associated with increased production of toxic amyloid beta42 peptides (see schematics). Abeta42 impairs synaptic function causing memory problems. We have recently found that similar changes in PS1 occur during aging and are observed in sporadic AD cases, which means that there are some factors in our brains (not a mutation) that cause these pathogenic changes in PS1 protein geometry. My lab is currently looking for these factors as potential new therapeutic targets to stop or prevent AD pathogenesis. Here is another slide from our “Working hypothesis” series, showing a vicious circle with different stressors causing change in PS1 leading to increased Abeta42, which further triggers calcium dishomeostasis, inflammation, reactive oxygen species generation, etc. (Fig.1). Blue “clump” is an amyloid beta plaque (senile plaque) that deposits in the brain of AD patients but is also observed in ~25-30% of cognitively normal aging adults.  An example of a drug Diazepam (Valium) is given in your textbook at the beginning of Chapter 9. Elaborate and/or propose other examples of how changes in the molecular architecture of a compound affect its properties and/or effectiveness of binding to a specific cell receptor. The disease results from a mis-folded protein which is the consequence of the molecular geometries of the molecules that make up the protein structure.Feel free also to discuss some real life examples of when enthalpies are important to us.

Order a unique copy of this paper
(550 words)

Approximate price: $22

Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
$26
The price is based on these factors:
Academic level
Number of pages
Urgency

Order your essay today and save 10% with the discount code DHCOVID10